HIV-1 accessory proteins are key for viral replication in vivo, yet these proteins lack enzymatic activity.
We aim to understand how Nef and Vpu form specific interactions with host cellular proteins to modify the cell surface landscape of host receptors.
We study how interactions between the HIV-1 protein Nef and PACS-1 or PACS-2 mediate immune escape in infected cells.
Additionally, we study the fundamental membrane trafficking roles undertaken by PACS-1 and PACS-2 in uninfected cells.
At Western, we have access to multiple equipment platforms that enable us to realize our research projects.
These include access to containment 2+ and 3 labs within the Imaging Pathogens for Knowledge Translation (ImPaKT) Facility along with the London Regional Flow Cytometry Facility and the London Regional Cell and In Vitro Molecular Imaging Facility housed in the Robarts Research Institute.