Selected Publications

HIV-1 Vpu Downregulates Tim-3 from the Surface of Infected CD4+ T Cells. Prévost J, Edgar CR, Richard J, Trothen SM, Jacob RA, Mumby MJ, Pickering S, Dubé M, Kaufmann DE, Kirchhoff F, Neil SJD, Finzi A, Dikeakos JD. J Virol, 2020; 94(7)

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Upregulation of BST-2 by Type I Interferons Reduces the Capacity of Vpu To Protect HIV-1-Infected Cells from NK Cell Responses. Prévost J, Pickering S, Mumby MJ, Medjahed H, Gendron-Lepage G, Delgado GG, Dirk BS, Dikeakos JD, Stüzel CM, Sauter D, Kirchhoff F, Bibollet-Ruche F, Hahn BH, Dubé M, Kaufmann DE, Neil SJD, Finzi A, Richard J. mBio, 2019; 10(3)

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PACS-1 and adaptor protein-1 mediate ACTH trafficking to the regulated secretory pathway. Dirk BS, End C, Pawlak EN, Van Nynatten LR, Jacob RA, Heit B, Dikeakos JD. Biochem Biophys Res Commun, 2018; 507(1-4)

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Identification of Novel Subcellular Localization and Trafficking of HIV-1 Nef Variants from Reference Strains G (F1.93.HH8793) and H (BE.93.VI997). Van Nynatten LR, Johnson AL, Dirk BS, Pawlak EN, Jacob RA, Haeryfar SMM, Dikeakos JD. Viruses, 2018; 10(9)

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The HIV-1 accessory proteins Nef and Vpu downregulate total and cell surface CD28 in CD4+ T cells. Pawlak EN, Dirk BS, Jacob RA, Johnson AL, Dikeakos JD. Retrovirology, 2018; 15(1)

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HIV-I Nef inhibitors: a novel class of HIV-specific immune adjuvants in support of a cure. Dekaban GA, Dikeakos JD.AIDS Res Ther, 2017; 14(1)

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The interaction between HIV-1 Nef and adaptor protein-2 reduces Nef-mediated CD4+ T cell apoptosis. Jacob RA, Johnson AL, Pawlak EN, Dirk BS, Van Nynatten LR, Haeryfar SMM, Dikeakos JD. Virology, 2017; 509

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A highly conserved residue in HIV-1 Nef alpha helix 2 modulates protein expression. Johnson AL, Dirk BS, Coutu M, Haeryfar SMM, Arts EJ, Finzi A, Dikeakos JD. mSphere, 2016; 1(6)

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Where in the cell are you? Probing HIV-1 host interactions through advanced imaging techniques. Dirk BS, Van Nynatten LR, Dikeakos JD.Viruses, 2016; 8(10)

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HIV-1 Nef sequesters MHC-I intracellularly by targeting early stages of endocytosis and recycling. Dirk BS, Pawlak EN, Johnson AL, Van Nynatten LR, Jacob RA, Heit B, Dikeakos JD. Sci Rep, 2016; 6(1)

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Viral bimolecular fluorescence complementation: a novel tool to study intracellular vesicular trafficking pathways. Dirk BS, Jacob RA, Johnson AL, Pawlak EN, Cavanagh PC, Van Nynatten LR, Haeryfar SMM, Dikeakos JD. PLoS One, 2015; 10(4)

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HIV-1 Nef: a master manipulator of the membrane trafficking machinery mediating immune evasion. Pawlak EN, Dikeakos JD. Biochim Biophys Acta Gen Subj, 2015; 1850(4)

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Visualizing interactions between HIV-1 Nef and host cellular proteins using ground-state depletion microscopy. Dirk BS, Heit B, Dikeakos JD. AIDS Res Hum Retroviruses, 2015; 31(7)

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MIiSR: molecular interactions in super-resolution imaging enables the analysis of protein interactions, dynamics and formation of multi-protein structures. Caetano FA, Dirk BS, Tam JHK, Cavanagh PC, Goiko M, Ferguson SSG, Pasternak SH, Dikeakos JD, de Bruyn JR, Heit B. PLoS Comput Biol, 2015; 11(12)

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An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I. Dikeakos JD, Thomas L, Kwon G, Elferich J, Shinde U, Thomas G. Mol Biol Cell, 2012; 23(11)

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Small Molecule Inhibition of HIV-1–Induced MHC-I Down-Regulation Identifies a Temporally Regulated Switch in Nef Action. Dikeakos JD, Atkins KM, Thomas L, Emert-Sedlak L, Byeon IJL, Jung J, Ahn J, Wortman MD, Kukull B, Saito M, Koizumi H, Williamson DM, Hiyoshi M, Barklis E, Takiguchi M, Suzu S, Gronenborn AM, Smithgall TE, Thomas G. Mol Biol Cell, 2010; 21(19)

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Functional and structural characterization of a dense core secretory granule sorting domain from the PC1/3 protease. Dikeakos JD, Di Lello P, Lacombe MJ, Ghirlando R, Legault P, Reudelhuber TL, Omichinski JG. Proc Natl Acad Sci U S A, 2009; 106(18)

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