Publications

Bimolecular Fluorescence Complementation to Visualize Protein–Protein Interactions in Cells. Edgar CE, Dikeakos JD Fluorescent Microscopy, 2022; p.91-97

Identification of a SARS-CoV-2 host metalloproteinase-dependent entry pathway differentially used by SARS-CoV-2 and variants of concern Alpha, Delta, and Omicron. Benlarbi M, Laroche G, Fink C, Fu K, Mulloy RP, Phan A, Ariana A, Stewart CM, Prévost J, eaudoin-Bussi&eegrave;res G, Daniel R, Bo Y, Yockell-Leli&eegrave;vre J, Stanford WL, Gigu&eegrave;re PM, Mubareka S, Finzi A, Dekaban GA, Dikeakos JD, Côté M bioRxiv, 2022; Pre-print

PACS‐1 contains distinct motifs for nuclear‐cytoplasmic transport and interacts with the RNA‐binding protein PTBP1 in the nucleus and cytosol. Trothen SM, Zang RX, Lurie A, Dikeakos JD FEBS lett, 2022; 596(2)

Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy. Ullah I, Prévost J, Ladinsky MS, Stone H, Lu M, Anand SP, Beaudoin-Bussi&eegrave;res G, Symmes K, Benlarbi M, Ding S, Gasser R, Fink C, Chen Y, Tauzin A, Goyette G, Bourassa C, Medjahed H, Mack M, Chung K, Wilen CB, Dekaban GA, Dikeakos JD, Bruce EA, Kaufmann DE, Stamatatos L, McGuire AT, Richard J, Pazgier M, Bjorkman PJ, Mothes W, Finzi A, Kumar P, Uchil PD Immunity, 2021; 54(9)

The HIV-1 accessory protein Nef increases surface expression of the checkpoint receptor Tim-3 in infected CD4+ T cells. Jacob RA, Edgar CE, Prévost J, Trothen SM, Lurie A, Mumby MJ, Galbraith A, Kirchhoff F, Haeryfar SMM, Finzi A, Dikeakos JD J Biol Chem, 2021; 297(3)

An amino acid polymorphism within the HIV-1 Nef dileucine motif functionally uncouples cell surface CD4 and SERINC5 downregulation. Mumby MJ, Johnson AL, Trothen SM, Edgar CR, Gibson R, Stathopulos PB, Arts EJ, Dikeakos JD Virol J, 2021; 95(16)

Major role of IgM in the neutralizing activity of convalescent plasma against SARS-CoV-2. Gasser R, Cloutier M, Prévost J, Fink C, Ducas É, Ding S, Dussault N, Landry P, Tremblay T, Laforce-Lavoie A, Lewin A, Beaudoin-Bussi&eegrave;res G, Laumaea A, Medjahed H, Larochelle C, Richard J, Dekaban GA, Dikeakos JD, Bazin R, Finzi A. Cell rep, 2021; 34(9)

Rapid removal of phagosomal ferroportin in macrophages contributes to nutritional immunity. Flannagan RS, Farrell TJ, Trothen SM, Dikeakos JD, Heinrichs DE. Blood Adv, 2021; 5(2)

Kidney injury molecule 1 is a receptor for SARS-CoV-2 in lung and kidney. Mori Y, Ichimura T, Fink C, Aschauer P, Das KMP, Padera RF, Weins A, Dekaban GA, Dikeakos JD, Nasr ML, Bonventre JV. J Am Soc Nephrol, 2021; p.59-59

Magnetic Particle Imaging is a sensitive in vivo imaging modality for the quantification of dendritic cell migration. Gevaert JJ, Fink C, Dikeakos JD, Dekaban GA, Foster PJ. bioRxiv, 2021; Pre-print

KIM-1/TIM-1 is a Receptor for SARS-CoV-2 in Lung and Kidney. Mori Y, Fink C, Ichimura T, Sako K, Mori M, Lee NN, Aschauer P, Das KMP, Hong S, Song M,Padera Jr RF, Weins A,Lee LP, Nasr ML, Dekaban GA, Dikeakos JD, Bonventre JV. medRxiv, 2020; Pre-print

Quantification and characterization of granulocyte macrophage colony-stimulating factor activated human peripheral blood mononuclear cells by fluorine-19 cellular MRI in an immunocompromised mouse model. Fink C, Smith M, Sehl OC, Gaudet JM, Meagher TC, Sheikh NA, Dikeakos JD, Rieder MJ, Foster PJ, Dekaban GA. Diagn Interv Imaging, 2020; 101(9)

The hematopoietic transcription factor GATA2 is a novel regulator of apoptotic cell clearance by macrophages in atherosclerosis. Yin C, Vrieze AM, Akingbasote J, Pawlak EN, Jacob RA, Hu J, Sharma N, Blackler G, Dikeakos JD, Barra L, Nagpal D, Heit B. J Am Coll Cardiol, 2020; 75(11)

HIV-1 Vpu Downregulates Tim-3 from the Surface of Infected CD4+ T Cells. Prévost J, Edgar CR, Richard J, Trothen SM, Jacob RA, Mumby MJ, Pickering S, Dubé M, Kaufmann DE, Kirchhoff F, Neil SJD, Finzi A, Dikeakos JD. J Virol, 2020; 94(7)

Upregulation of BST-2 by Type I Interferons Reduces the Capacity of Vpu To Protect HIV-1-Infected Cells from NK Cell Responses. Prévost J, Pickering S, Mumby MJ, Medjahed H, Gendron-Lepage G, Delgado GG, Dirk BS, Dikeakos JD, Stüzel CM, Sauter D, Kirchhoff F, Bibollet-Ruche F, Hahn BH, Dubé M, Kaufmann DE, Neil SJD, Finzi A, Richard J. mBio, 2019; 10(3)

PACS-1 and adaptor protein-1 mediate ACTH trafficking to the regulated secretory pathway. Dirk BS, End C, Pawlak EN, Van Nynatten LR, Jacob RA, Heit B, Dikeakos JD. Biochem Biophys Res Commun, 2018; 507(1-4)

Identification of Novel Subcellular Localization and Trafficking of HIV-1 Nef Variants from Reference Strains G (F1.93.HH8793) and H (BE.93.VI997). Van Nynatten LR, Johnson AL, Dirk BS, Pawlak EN, Jacob RA, Haeryfar SMM, Dikeakos JD. Viruses, 2018; 10(9)

The HIV-1 accessory proteins Nef and Vpu downregulate total and cell surface CD28 in CD4+ T cells. Pawlak EN, Dirk BS, Jacob RA, Johnson AL, Dikeakos JD. Retrovirology, 2018; 15(1)

HIV-I Nef inhibitors: a novel class of HIV-specific immune adjuvants in support of a cure. Dekaban GA, Dikeakos JD.AIDS Res Ther, 2017; 14(1)

The interaction between HIV-1 Nef and adaptor protein-2 reduces Nef-mediated CD4+ T cell apoptosis. Jacob RA, Johnson AL, Pawlak EN, Dirk BS, Van Nynatten LR, Haeryfar SMM, Dikeakos JD. Virology, 2017; 509

A highly conserved residue in HIV-1 Nef alpha helix 2 modulates protein expression. Johnson AL, Dirk BS, Coutu M, Haeryfar SMM, Arts EJ, Finzi A, Dikeakos JD. mSphere, 2016; 1(6)

Where in the cell are you? Probing HIV-1 host interactions through advanced imaging techniques. Dirk BS, Van Nynatten LR, Dikeakos JD.Viruses, 2016; 8(10)

HIV-1 Nef sequesters MHC-I intracellularly by targeting early stages of endocytosis and recycling. Dirk BS, Pawlak EN, Johnson AL, Van Nynatten LR, Jacob RA, Heit B, Dikeakos JD. Sci Rep, 2016; 6(1)

Viral bimolecular fluorescence complementation: a novel tool to study intracellular vesicular trafficking pathways. Dirk BS, Jacob RA, Johnson AL, Pawlak EN, Cavanagh PC, Van Nynatten LR, Haeryfar SMM, Dikeakos JD. PLoS One, 2015; 10(4)

HIV-1 Nef: a master manipulator of the membrane trafficking machinery mediating immune evasion. Pawlak EN, Dikeakos JD. Biochim Biophys Acta Gen Subj, 2015; 1850(4)

Visualizing interactions between HIV-1 Nef and host cellular proteins using ground-state depletion microscopy. Dirk BS, Heit B, Dikeakos JD. AIDS Res Hum Retroviruses, 2015; 31(7)

MIiSR: molecular interactions in super-resolution imaging enables the analysis of protein interactions, dynamics and formation of multi-protein structures. Caetano FA, Dirk BS, Tam JHK, Cavanagh PC, Goiko M, Ferguson SSG, Pasternak SH, Dikeakos JD, de Bruyn JR, Heit B. PLoS Comput Biol, 2015; 11(12)

An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I. Dikeakos JD, Thomas L, Kwon G, Elferich J, Shinde U, Thomas G. Mol Biol Cell, 2012; 23(11)

Small Molecule Inhibition of HIV-1–Induced MHC-I Down-Regulation Identifies a Temporally Regulated Switch in Nef Action. Dikeakos JD, Atkins KM, Thomas L, Emert-Sedlak L, Byeon IJL, Jung J, Ahn J, Wortman MD, Kukull B, Saito M, Koizumi H, Williamson DM, Hiyoshi M, Barklis E, Takiguchi M, Suzu S, Gronenborn AM, Smithgall TE, Thomas G. Mol Biol Cell, 2010; 21(19)

Functional and structural characterization of a dense core secretory granule sorting domain from the PC1/3 protease. Dikeakos JD, Di Lello P, Lacombe MJ, Ghirlando R, Legault P, Reudelhuber TL, Omichinski JG. Proc Natl Acad Sci U S A, 2009; 106(18)